Pregnancy and Anti-D

Rh (D) Antenatal Prophylaxis Program

Australia is now at Stage 3 of the Rh (D) Antenatal Prophylaxis Program


Antenatal and postnatal prophylaxis for all Rh (D) negative women using solely Australian Rh (D) immunoglobulin (Anti-D)

Since 31 March 2006, Australia has been self-sufficient in its supply of Rh (D) immunoglobulin (Anti-D). Routine Rh (D) antenatal and postnatal prophylaxis can now be given to all Rh (D) negative women without pre-formed Anti-D using solely Australian Rh (D) immunoglobulin.

A letter of announcement about self-sufficiency can be read here

In brief, Stage 3 means that Rh (D)immunoglobulin products should be used as indicated below;

  • First trimester sensitising events1 (<12 weeks): Rh (D) Immunoglobulin 250 IU
  • First trimester sensitising events1 (multiple pregnancies <12 weeks): Rh (D) Immunoglobulin 625 IU
  • Second and third trimester sensitising1 events: Rh (D) immunoglobulin 625 IU
  • All Rh (D) negative women without preformed Anti-D: Rh (D) Immunoglobulin 625 IU at 28 and 34 weeks gestation
  • Postnatal prophylaxis: Rh (D) Immunoglobulin 625 IU

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