THROMBOTROL–VF (Antithrombin) III
Indications for Use
Thrombotrol-VF is indicated in patients with hereditary deficiency of antithrombin III(ATIII) under the following circumstances:
- Prophylactic administration for the prevention of thrombosis and pulmonary embolism in surgery, pregnancy and childbirth.
- Therapeutic administration in thrombosis or pulmonary embolism.
- Also used for acquired deficiencies such as liver disease and acute DIC.
Availability
Usually issued on an individual patient basis following approval by an ARCBS Haematologist/ Medical Officer. Hospitals may request supplies for stock from ARCBS.
Precautions
Interactions with other drugs: concurrent therapy with Thrombotrol-VF may enhance the anticoagulant effect of heparin.
Dosage and Administration
An individual patient's dose should be determined using the pre-treatment and desired plasma ATIII levels.
When an infusion of Thrombotrol-VF is indicated for a patient with hereditary deficiency of AT to control an acute thrombotic episode or prevent thrombosis following surgical or obstetrical procedures, it is desirable to raise the ATIII levels to normal.
The duration of treatment for which this level needs to be maintained is not established and will depend on the indication for treatment, type and extent of surgery, patient's medical condition, past history and physician's judgment.
Refer to the current product information sheet for further information.