Product Description
All Cryoprecipitate
- Contains high levels of FVIII, fibrinogen, Factor XIII, VWF and fibronectin.
- Stored frozen (colder than -25ºC) with a shelf life of up to 12 months.
|
| Cryoprecipitate | Prepared by thawing FFP between 1º and 6º C and recovering the precipitate. This precipitate is then refrozen. | 30-40mL |
| Cryoprecipitate Apheresis | Prepared by thawing apheresis FFP between 1º and 6º C and recovering the precipitate. This precipitate is then refrozen. | 60mL ± 10% |
Modifications Available
No modifications available.
Indications for Use
Indicated for the treatment of:
- Fibrinogen deficiency (based on laboratory results and clinical condition)
- Dysfibrogenaemia
When there is clinical bleeding, invasive procedures, trauma or disseminated intravascular coagulation (DIC).
Precautions
Should not be used for the treatment of haemophilia, von Willebrand’s disease or deficiencies of FXIII or fibronectin unless alternative therapies (e.g. factor concentrates) are unavailable.
Compatibility
TESTING - blood group on record.
Compatibility testing is not required however ABO compatible plasma should be used wherever possible.
Group AB plasma can be used for all ABO groups in an emergency.
Rh(D) matching is unnecessary.
ABO incompatible cryoprecipitate can be used with caution, particularly in large volumes.
ABO
|
| A | A, AB |
| B | B, AB |
| AB | AB |
| O | O, AB, A, B |
Note: AB Cryoprecipitate may be used for all patient ABO groups.
Dosage and Administration
- Volume depends on clinical situation, patient size and laboratory tests. A common dose for fibrinogen replacement is a unit for each 10kg patient body weight.
- Discuss with your Haematologist or ARCBS TMS team. For patients with specific factor deficiencies, always consider specific replacement therapy e.g. Factor VIII for haemophilia A, rather than cryoprecipitate.
- Once thawed, use immediately and compete transfusion within four hours of thawing.
Transfusion Set-up
Note: this is a guide only – individual hospital guidelines should be followed
- Mix gently but thoroughly by inversion prior to use
- Administer cryoprecipitate through a new IV blood giving set incorporating a 170-200 micron filter (large particle filter which only removes aggregates and other large particles)
Patient Monitoring
Note: this is a guide only – individual hospital guidelines should be followed.
- Start transfusion as soon as possible after thawing of Cryoprecipitate
- Check patient vital signs (pulse rate, respiration rate, blood pressure and temperature) at the start of the transfusion AND at least after 15 minutes, at the end of the transfusion AND if there is ANY reaction. Record observations in patient’s notes.
How Long Should a Transfusion Take?
- Transfusion of each unit may proceed as fast as tolerated but should be completed within four hours of commencing the transfusion.